Monitor therapyĪllopurinol: Thiazide and Thiazide-Like Diuretics may enhance the potential for allergic or hypersensitivity reactions to Allopurinol. Monitor therapyĪlfuzosin: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Alcohol (Ethyl) may increase the serum concentration of Propranolol. Monitor therapyĪlcohol (Ethyl): May decrease the serum concentration of Propranolol. Specifically, the risk for cholestasis may be increased. Monitor therapyĪjmaline: Sulfonamides may enhance the adverse/toxic effect of Ajmaline. Monitor therapyĪjmaline: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Consider therapy modificationĪcetylcholinesterase Inhibitors: May enhance the bradycardic effect of Beta-Blockers. When concurrent use is not avoidable, monitor patients closely for signs/symptoms of toxicity. Management: Avoid concurrent use of abiraterone with CYP2D6 substrates that have a narrow therapeutic index whenever possible.
See “Warnings/Precautions” for more detail.ĭocumentation of allergenic cross-reactivity for thiazide-related diuretics is limited. Note: Although some product labeling states this medication is contraindicated with other sulfonamide-containing drug classes, the scientific basis of this statement has been challenged. Hypersensitivity to propranolol, hydrochlorothiazide, other beta-blockers, other sulfonamide-derived drugs, or any component of the formulation heart failure (unless the failure is due to tachyarrhythmias being treated with propranolol) cardiogenic shock sinus bradycardia heart block greater than first-degree bronchial asthma anuria
Hypertension: Management of hypertension. Hydrochlorothiazide: Inhibits sodium reabsorption in the distal tubules causing increased excretion of sodium and water as well as potassium and hydrogen ions. Reduces portal pressure by producing splanchnic vasoconstriction (beta2 effect) thereby reducing portal blood flow.
Propranolol: Competitively blocks response to beta1- and beta2-adrenergic stimulation which results in decreases in heart rate, myocardial contractility, blood pressure, and myocardial oxygen demand.